Endocrine Abstracts

Indications to GH therapy in children with short stature are still a matter of discussion.We compared first-year response to GH therapy in 80 children (62 boys, 18 girls), age 12.7±2.4 years (mean±S.D.) with different disorders of GH secretion. In all the patients nocturnal GH secretion assessed during 3 h after falling asleep was decreased (<10 ng/ml). In 40 children GH deficiency (GHD) was diagnosed on the ground of decreas...

Normal thyroid hormone secretion (or appropriate L-thyroxin substitution) is necessary for the optimal effect GH administration on growing rate. The decrease of free thyroxin (FT4) levels at GH therapy onset was reported in several studies.The aim of our study was to assess the incidence of hypothyroidism (HT) during the initial phase of GH administration in previously euthyroid children with GH deficiency (GHD) and to compare t...

Hyperprolactinemia may lead to bone loss, both due to hypogonadism and other hormonal disturbances.Aim: Aim of the study was the analysis of influences of hormonal profiles associated with hyperprolactinemia on bone mineral density (BMD) and bone turnover in women with hyperprolactinemia of various origin. The subjects were 32 patients with prolactinoma, 43 ones with functional hyperprolactinemia and 29 healthy controls. All of them were studied BMD (lum...

Background: Nocturnal profile of GH secretion is proposed to be a screening diagnostic procedure for GH deficiency (GHD) in short children. Every screening procedure must be characterised by very high sensitivity and good specificity. The data concerning the cut-off level between normal and subnormal nocturnal GH secretion are scarce and non-consistent.The aim of the study was to assess the clinical utility of 2-h nocturnal profile of GH secretion in dia...

Background: Assessment of nocturnal GH secretion is useful tool in diagnosing GH deficiency (GHD) in children. The time period of the evaluation, the number of blood samples, as well as the choice of cut-off value for this examination – are still the matter for discussion.Aim: The aim of the study was to compare the results of 2-h and 6-h assessment of nocturnal GH secretion in children with suspected neurosecretory dysfunction of GH secretion (NSD)...

Fetal undernutrition is at the base of disorders in the differentiation process of pancreatic beta cells. Abnormal insulin activity leads to restriction of fetal growth and to obesity, insulin resistance and diabetes mellitus type 2 (DM2), either in childhood or adulthood. The aim of the study was to assess the incidence of obesity and insulin resistance in prepubertal children, born with body mass too small for their gestational age (SGA).Material and m...

The clinical picture of hypothyroidism is well described. It is well known that thyroid hormones are very important to development and maturation of the central nervous system. They have influence on the synthesis of proteins and production of enzymes and myelin.Myelin synthesis is an important factor in determining the speed of impulse transmission along complex polysynaptic pathways, such as those mediating the evoked potentials....

Until recently primary aldosteronism /PA/ was thought to be rare, accounting for no more than 0.05–2% of the hypertensive patients. Studies published in the last decade demonstrate that primary hyperaldosteronism is a much more common cause of secondary hypertension than was previously thought, accounting for as many as 5% to 25% of hypertensives in some series. For the present, there are no data concerning the prevalence of PA in Bulgaria which determined the realization...

Introduction: Acromegaly with normal IGF-1level is rarely diagnosed and is difficult to recognize. In acromegalic pa-tients with poorly controlled diabetes, malnutrition, hepatic injury, hepatic congestion due to heart fail-ure, inflammatory diseases, renal dysfunction, and malignant neoplasm, IGF-1 synthesis is inhibited and thus in such cases normal IGF-1 levels may be observed. The aim of the study is to present a rare case of a patient with acromegaly and normal IGF-1 leve...

Introduction: Chemodectomas of carotid glomus secret mainly catecholamines and/or ACTH. These tumours are very rare cause of ectopic secretion of parathormone (PTH), althought this possibility should be taken into consideration. Therefore, diagnosis of primary hyperparathyroidism (PHPT) as a cause of hypercalcemia in patients with chemodectoma tumours is problematic and may lead to inappropriate diagnosis and treatment. Presented patient is a 64-years old female with non-opera...